The human body has an intricate immune system designed to protect the body from harmful agents like bacteria and viruses. Unfortunately, certain conditions can cause the immune system to attack its own body tissues, which leads to autoimmune disorders.
About eighty autoimmune diseases have been identified in humans to date, typically divided into “organ-specific” disorders and “non-organ-specific” disorders, which affect multiple parts of the body.
Parkinson’s disease, which affects nearly one million Americans and 10 million people worldwide, is typically classified as a brain disorder, though new research suggests autoimmunity may play a role in the development of the disease. Though more research is still needed, many studies have begun classifying Parkinson’s as an autoimmune disease.
So what exactly is Parkinson’s disease, what causes it, and what treatment options are available, if any? Let’s take a closer look at this condition and explore whether it can affect things like blood sugar levels.
Parkinson’s disease is a neurodegenerative disorder in which a person’s motor features become damaged, causing mobility issues, resting trembling, muscle rigidity, and reduced muscle control. This movement disorder appears when the nerve cells stop producing dopamine, a neurotransmitter used by the nervous system to send messages to the part of the brain that controls movement and coordination. Some experts believe the condition can develop due to problems in how the body uses a protein called alpha-synuclein. Parkinson’s disease is also sometimes attributed to the damage to the nerve cells that produce another important chemical substance called norepinephrine, which is involved in blood circulation. Some specific proteins become damaged in time, and they start forming clumps that build up in the brain cells that produce dopamine, leading to cell death and causing a slow cognitive decline. You cannot bring cells back to life, so an early diagnosis of the disease can prevent cell damage and other complications.
Unfortunately, once Parkinson’s disease takes effect, there is no cure for reversing the degeneration of neurons. While some studies consider genetics a cause of Parkinson’s, others speculate that it can occur due to prolonged exposure to environmental factors. However, we still need more research on this topic.
Parkinson’s is generally more prevalent among men. Of course, the disease affects quality of life and is challenging to deal with for those who have it. But it also affects families and caregivers because patients may become dependent on the people around them as their disease progresses.
Imagine what it would feel like if you couldn’t hold a fork, a glass of water, or a pen anymore due to extreme trembling. The first stages of Parkinson’s are easily recognizable, beginning with slight tremors on one side of the body, a soft voice, a slow blink rate, loss of sense of smell, slow movements, and balance difficulties.
These are followed by subtle signs that affect daily living, such as a slight voice tremor, lip and jaw tremor, fixed facial expressions, and even tongue tremor, making it hard for the patients to speak properly. Usually, these symptoms appear when at least fifty percent of the neurons are lost, so the early stages of the disorder are harder to be recognized and have already begun affecting the patient’s quality of life.
Some of the most common Parkinson’s disease symptoms are:
The late stages of the disease come with many health complications, such as gait freezing (when the feet are unable to walk) or even falling, dementia, delusions, or hallucinations. Patients in the last stage of Parkinson’s are also susceptible to pneumonia, which can be deadly.
Parkinson’s disease can be hard to detect as no specific tests are associated with its diagnosis, and risk factors are generally unknown. The most precise method currently used to diagnose this condition is the patient’s medical history and a neurological examination searching for clinical criteria of the disease.
Clinicians will review the patient’s history and analyze present symptoms to rule out other possible diagnoses. Genetic factors and family members who may have been previously affected by this condition can also make it easier to determine if the patient has a higher chance of developing Parkinson’s.
Blood tests and additional testing may help with diagnosis as they can identify elevated cholesterol levels and environmental toxins like carbon disulfide, herbicides, and pesticides present in the bloodstream.
If a patient shows symptoms consistent with Parkinson’s, their doctor may also order imaging tests such as MRI to search for neurological abnormalities and rule out other possible conditions. Head traumas, inflammation, and genetic mutations are also factors that can lead to the diagnosis of Parkinson’s disease.
Treatment of Parkinson’s disease can vary as Parkinson’s currently does not have a known cure. The current treatment options available aim to slow the disease’s progression and improve the patient’s functional capacity for as long as possible.
Healthcare professionals often recommend levodopa, a naturally occurring amino acid first introduced in the 1960s, metabolized to dopamine in the brain.
While it is still considered the most effective option, long-term use can lead to different health complications such as motor fluctuations and dyskinesias.
Patients treated with levodopa can also experience side effects such as nausea and lightheadedness.
Dopaminergic medication is an excellent second treatment option, as it improves the dopamine levels in the body. Unlike levodopa, dopamine agonists mimic the effects of dopamine in the brain rather than converting it into the chemical themselves.
Side effects of dopamine agonists can include hallucinations, sleepiness, and compulsive out-of-character behaviors, so this treatment option might not be suitable for people who have experienced psychosis or depression.
Other treatment options can sometimes include deep brain stimulation, which functions through a device implanted in the brain to deliver electrical currents. Its effects are similar to those of levodopa and generally are effective for Parkinson’s patients as well as people who have epilepsy.
Apart from medicinal treatment, other forms of therapy can help improve symptoms of Parkinson’s disease. Doing regular physical exercise can improve motor skills and muscle strength, slowing down the rigidity process.
Taking regular walks or engaging in dance therapy is especially recommended for patients with an early diagnosis. Speech therapy and voice treatment can also improve volume and diction.
High blood sugar levels can lead to type 2 diabetes, a chronic illness in which the body becomes resistant to insulin. Insulin is a vital hormone responsible for transporting glucose from the blood to the cells to provide energy to the body. If the body becomes resistant to insulin, glucose stays in the blood for a longer time, causing many health complications.
Parkinson’s disease and type 2 diabetes have been found to share many common pathophysiological mechanisms.
New research suggests a possible link between nerve cell degeneration, which can lead to diabetes, and Parkinson’s disease. Insulin resistance is present in both individuals with diabetes and those with Parkinson’s, so improving our blood glucose levels by reducing the glucose intake may help reduce the risks of both diseases.
Eating a healthy and nutritious diet is one of the best habits you can introduce into your lifestyle to prevent disease. The Parkinson’s Foundation recommends a balanced diet full of whole grains, fruits and vegetables, dairy, and protein-rich foods to stay on top of your health and get plenty of exercise. However, everyone is different, and it’s important to test your body’s unique response.
For individuals already diagnosed with Parkinson’s, professionals recommend staying hydrated, limiting sugar and caffeine intake, and increasing fiber intake to aid digestion.
When considering supplementation, always talk with a credentialed health provider, however a good place to start is by boosting your vitamins and minerals through food. Try adding fatty fish to your diet to boost omega-3, eating yogurt or fermented foods for extra probiotics, and things like good quality animal proteins, leafy greens, and eggs for sources of vitamin B.
Parkinson’s disease is a serious neurological disorder that can cause many health complications and affect your quality of life. It's important to monitor yourself for potential signs of its onset if you have a family history of the condition to best treat the disease.
NutriSense allows you to work with credentialed dietitians and nutritionists who can guide you and provide valuable information about maintaining a healthy lifestyle.
As a member of the NutriSense CGM program, you’ll be able to monitor your body’s response to food and access your body’s data and response to food and other factors in real-time with the help of CGM devices that can track your glucose levels.
Take control of your health and learn how monitoring your glucose and overall nutrition can help you prevent disease and feel better with NutriSense.
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